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• Organic acids and nature identical compounds can increase the activity of conventional antibiotics against Clostridium perfringens and Enterococcus cecorum in vitro

  OA and NIC were always effective in a dose-dependent manner, even when the antibiotics failed. For several strains, selected combinations of OA or NIC with antibiotics increased the bacterial sensitivity to antibiotics. Therefore, OA and NIC have potential to enhance the efficacy of conventional antibiotics against C. perfringens and E. cecorum.

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• Thymol and Carvacrol Downregulate the Expression of Salmonella typhimurium Virulence Genes during an In Vitro Infection on Caco-2 Cells

  A real-time PCR study highlighted a significant downregulation of the main virulence genes of Salmonella (hilA, prgH, invA, sipA, sipC, sipD, sopB, sopE2). These findings indicate that thymol and carvacrol could be good candidates for the control of Salmonella typhimurium in pigs.

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• Effects of increasing dietary level of organic acids and nature-identical compounds on growth, intestinal cytokine gene expression and gut microbiota of rainbow trout (Oncorhynchus mykiss) reared at normal and high temperature

  The application of the microencapsulate blend tested can be a useful strategy to improve growth and feed utilization in rainbow trout under normal temperature conditions. According to the results, organic acids and nature-identical compounds did not revert the effects triggered by the increased temperature of the water.

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• Single components of botanicals and nature-identical compounds as a non-antibiotic strategy to ameliorate health status and improve performance in poultry and pigs

  The use of NIC allows us to properly combine pure compounds, according to the target to achieve. Thus, they represent a promising non-antibiotic tool to allow better intestinal health and general health status, thereby leading to improved growth performance.

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• A microencapsulated feed additive containing organic acids, thymol, and vanillin increases in vitro functional activity of peripheral blood leukocytes from broiler chicks

  4 days of supplementation with a microencapsulated blend made up of citric and sorbic acids, thymol, and vanillin enhanced the in vitro PBL functions of degranulation, oxidative burst, and nitric oxide production compared with the control diet. Collectively, the data suggest feeding broiler chicks a diet supplemented with a microencapsulated blend of citric and sorbic acids, thymol, and vanillin may prime key immune cells making them more functionally efficient and acts as an immune-modulator to boost the inefficient and undeveloped immune system of young chicks.

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• Dietary supplementation with a microencapsulated blend of organic acids and botanicals alters the kinome in the ileum and jejunum of Gallus gallus

  The objective of this project was to determine if feeding a microencapsulated product comprised of a blend of organic acids and botanicals (AviPlus®P) impacts the intestinal kinome of broiler chickens (Gallus gallus).

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• Thymol modulates the endocannabinoid system and gut chemosensing of weaning pigs

  The purposes of this study were to investigate the presence of markers of the endocannabinoid system and the chemosensing system in the pig gut and, second, to determine if thymol modulates these markers.

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• Cannabinoid and Cannabinoid-Related Receptors in the Myenteric Plexus of the Porcine Ileum

  The endocannabinoid system (ECS) has opened the door to novel therapeutical approaches targeting cancer, pain, anxiety, stress, and inflammatory diseases. The ECS is ubiquitously expressed in almost all members of Animalia, but its precise localization outside the central nervous system is still under investigation.

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• Tributyrin differentially regulates inflammatory markers and modulates goblet cells number along the intestinal tract segments of weaning pigs

  Butyric acid is widely used in pig production as feed additive to improve growth performance at weaning, based on its intestinal health-promoting action. The aim of this study was to evaluate the intestinal architecture and expression of inflammatory cytokines and tight junctions (TJ) markers in weaning piglets fed with tributyrin, either free or microencapsulated, as dietary source of butyric acid.

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• Animal performance passes through gut health

  Intestinal health is one of the most important aspects of animal production. The intestine acts as the main line of defense against pathogens and it is the organ deputed to nutrient absorption. Both functions have pivotal importance for animal health and production.

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• Gut health is the key for animal health and production

  The general concern about animal welfare, especially for laying hens, is continuously increasing in consumers and farmers. This attention leads to spending time and efforts to understand if our birds are stressed or not, through many different indicators both deriving from animal observation (behavior, performance, fearfulness) and laboratory analysis (Alm et al., 2016; Rodenburg et al., 2008).

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• A microencapsulated blend of organic acids and natural identical flavours reduces necrotic enteritis-associated damages in broiler chickens

  Six-hundred ROSS 308 broilers were allocated in 24 pens divided into 3 experimental groups (d0): the control diet (CTR), the control diet added with Galliacid®S at 300 ppm (GAL S), a microencapsulated blend of organic acids and natural identical flavours (EU patent 1391155B1; Vetagro srl, Italy), and the control diet added with a different blend of organic acids (WSB) added at 300 ppm.

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